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Important Safety Information
Cialis® (Tadalafil)
Prescription MedicationCialis (tadalafil) is an FDA-approved prescription medication for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH) in adult men. Its extended half-life provides effectiveness for up to 36 hours, offering greater flexibility compared to shorter-duration PDE5 inhibitors. Cialis is available in as-needed doses (10mg or 20mg) and low-dose daily formulations (2.5mg or 5mg). A valid prescription from a licensed provider is required.
Emergency: If you experience chest pain, severe shortness of breath, a prolonged painful erection (over 4 hours), or sudden vision/hearing loss — call 911 or go to your nearest emergency room immediately.
Who Should Not Use Cialis® (Tadalafil)
- Women or children
- Men taking nitrate medications in any form (oral, sublingual, transdermal, or recreational)
- Men taking riociguat
- Individuals with a known hypersensitivity to tadalafil
- Men with severe hepatic impairment
- Men for whom sexual activity poses a significant cardiovascular risk
Warnings & Precautions
Nitrate Contraindication
Tadalafil combined with nitrates can cause a sudden and severe drop in blood pressure. This combination is strictly contraindicated and potentially life-threatening.
Duration of Action
Due to its 36-hour duration, tadalafil's effects and potential interactions extend beyond a single sexual encounter. This should be considered when managing other medications during this window.
Priapism
Seek emergency medical attention for any erection lasting more than 4 hours. Prolonged erections may result in permanent damage if untreated.
BPH & Cardiovascular Effects
In patients using Cialis for BPH, clinically significant hypotension may occur, particularly when combined with alpha-adrenergic antagonists. Appropriate dosing intervals should be observed.
Renal & Hepatic Considerations
Dose adjustment is required for patients with moderate or severe renal impairment. Use in severe hepatic impairment is not recommended.
Common Side Effects
This is not a complete list. Contact your provider if you experience any concerning symptoms.
- Headache
- Back pain or myalgia (more common with tadalafil than other PDE5 inhibitors)
- Facial flushing
- Nasal congestion
- Indigestion
- Limb pain
- Dizziness
Drug Interactions
Always inform your provider of all medications, supplements, and substances you are currently taking.
- Nitrates — strictly contraindicated (all forms)
- Riociguat — contraindicated
- Alpha-blockers — dose separation recommended to reduce hypotension risk
- Antihypertensives — additive blood pressure lowering possible
- CYP3A4 inhibitors (ketoconazole, erythromycin, ritonavir) — increase tadalafil exposure
- Rifampin and other CYP3A4 inducers — may significantly reduce tadalafil effectiveness
When to Contact Your Provider
- You experience sudden vision or hearing loss
- An erection lasts more than 4 hours
- You develop chest pain, severe dizziness, or syncope
- You take nitrate medications and have been prescribed Cialis in error
- You want to discuss switching between as-needed and daily dosing regimens
This safety information is provided for general educational purposes only and does not constitute medical advice. It is not a substitute for the full prescribing information, package insert, or guidance from your licensed healthcare provider. Individual responses to medications and supplements vary. MEDVera providers review your complete health profile before recommending or prescribing any treatment.