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Important Safety Information
Compounded Semaglutide Injection
Compounded Prescription MedicationCompounded semaglutide injection contains the same active ingredient (semaglutide) found in FDA-approved GLP-1 products, prepared by a licensed compounding pharmacy per an individual prescription. It is prescribed for chronic weight management under provider supervision. Compounded medications are not individually FDA-approved as a finished product, though semaglutide itself is an FDA-approved active ingredient.
Emergency: If you experience chest pain, severe shortness of breath, a prolonged painful erection (over 4 hours), or sudden vision/hearing loss — call 911 or go to your nearest emergency room immediately.
Who Should Not Use Compounded Semaglutide Injection
- Patients with a personal or family history of medullary thyroid carcinoma (MTC)
- Patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Anyone with a known hypersensitivity to semaglutide or any component of the compounded formulation
- Pregnant or breastfeeding individuals
- Patients with a history of pancreatitis without provider clearance
Warnings & Precautions
Thyroid C-Cell Tumors
Semaglutide causes dose-dependent thyroid C-cell tumors in rodents. Avoid use in patients with a personal or family history of MTC or MEN 2.
Pancreatitis
Acute pancreatitis has been reported. Discontinue immediately if suspected and do not restart without provider evaluation.
Compounding Considerations
Compounded formulations are prepared for your specific prescription by a licensed pharmacy and are not independently FDA-reviewed as a finished product; dosing and concentration should be confirmed with your provider before each fill.
Injection Site Rotation
Rotate injection sites weekly to minimize nodules, bruising, and local irritation.
Renal Impairment
Acute kidney injury has been reported, often associated with dehydration from GI side effects. Maintain adequate hydration.
Common Side Effects
This is not a complete list. Contact your provider if you experience any concerning symptoms.
- Nausea (most common, especially during dose escalation)
- Vomiting
- Diarrhea or constipation
- Abdominal pain
- Decreased appetite
- Injection site reactions
- Fatigue
Drug Interactions
Always inform your provider of all medications, supplements, and substances you are currently taking.
- Insulin and insulin secretagogues — increased hypoglycemia risk
- Oral medications — delayed gastric emptying may affect absorption
- Other GLP-1 receptor agonists — do not combine
When to Contact Your Provider
- Persistent vomiting or severe abdominal pain
- Signs of hypoglycemia if also on insulin/sulfonylureas
- Neck lump, difficulty swallowing, or persistent hoarseness
- Signs of kidney problems: decreased urination, leg/ankle swelling
This safety information is provided for general educational purposes only and does not constitute medical advice. It is not a substitute for the full prescribing information, package insert, or guidance from your licensed healthcare provider. Individual responses to medications and supplements vary. MEDVera providers review your complete health profile before recommending or prescribing any treatment.