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Important Safety Information
Valacyclovir (Valtrex)
Prescription AntiviralValacyclovir (brand name Valtrex) is an FDA-approved prescription antiviral medication used to treat and suppress outbreaks of herpes simplex virus (HSV-1 and HSV-2), genital herpes, and cold sores. It works by reducing the ability of the virus to multiply.
Emergency: If you experience chest pain, severe shortness of breath, a prolonged painful erection (over 4 hours), or sudden vision/hearing loss — call 911 or go to your nearest emergency room immediately.
Who Should Not Use Valacyclovir (Valtrex)
- Individuals with known hypersensitivity to valacyclovir or acyclovir
- Those with severely compromised immune systems without provider monitoring
- Individuals with severe renal impairment without dose adjustment
Warnings & Precautions
Kidney Function
Valacyclovir is cleared through the kidneys. Dose adjustments are required in individuals with reduced kidney function. Inform your provider of any kidney conditions.
Pregnancy & Breastfeeding
Valacyclovir may be used during pregnancy under provider guidance as the risk of untreated herpes outbreaks may outweigh medication risks. Discuss with your provider.
Not a Cure
Valacyclovir does not cure herpes infections. It reduces outbreak frequency, duration, and severity, and lowers (but does not eliminate) transmission risk.
Common Side Effects
This is not a complete list. Contact your provider if you experience any concerning symptoms.
- Headache (most common)
- Nausea
- Abdominal pain
- Dizziness
- Rare: confusion or neurological symptoms (more common with high doses in elderly or immunocompromised)
Drug Interactions
Always inform your provider of all medications, supplements, and substances you are currently taking.
- Nephrotoxic medications (may increase kidney toxicity risk)
- Probenecid (increases valacyclovir levels)
- Cimetidine (increases acyclovir exposure)
When to Contact Your Provider
- Signs of kidney problems (decreased urination, swelling, unusual fatigue)
- Confusion, hallucinations, or seizures (rare but serious)
- Signs of serious allergic reaction
- Outbreak frequency not improving with suppressive therapy
This safety information is provided for general educational purposes only and does not constitute medical advice. It is not a substitute for the full prescribing information, package insert, or guidance from your licensed healthcare provider. Individual responses to medications and supplements vary. MEDVera providers review your complete health profile before recommending or prescribing any treatment.